Mayaro Virus: The State-of-the-Art for Antiviral Drug Development

Area of Science:

• Virology
• Infectious Diseases
• Drug Discovery

Background:

• Mayaro virus (MAYV) is an emerging arbovirus in the Togaviridae family, causing febrile and arthralgia syndromes.
• MAYV outbreaks are increasing in Brazil, spreading to new regions, and its symptoms are often confused with other arboviruses.
• Current management for MAYV infection is limited to symptom relief due to the absence of specific antiviral drugs or prophylactic measures.

Purpose of the Study:

• To review the current landscape of antiviral compound and molecule development against Mayaro virus.
• To identify potential therapeutic strategies for inhibiting MAYV infection and managing its symptoms.

Main Methods:

• Literature review of scientific databases for studies on Mayaro virus.
• Analysis of research on antiviral compounds and molecules with potential activity against MAYV.
• Synthesis of current knowledge on Mayaro virus screening and drug development.

Main Results:

• The review highlights the urgent need for specific treatments against MAYV.
• Several classes of compounds are being investigated for their potential anti-MAYV activity.
• Challenges in MAYV diagnosis and treatment are discussed, emphasizing the importance of ongoing research.

Conclusions:

• There is a critical need for the development of specific antiviral therapies for Mayaro virus.
• Ongoing research into novel compounds and molecules shows promise for future MAYV treatment strategies.
• Further investigation is required to advance the screening and development of effective anti-MAYV agents.