Related Experiment Video
Updated: Aug 30, 2025
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Endovascular treatment for distal basilar artery occlusion stroke
Jiaxing Song1, Zhou Yu2, Jian Wang3
1Department of Neurology, Xinqiao Hospital and The Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Insights
Endovascular treatment (EVT) for distal basilar artery occlusion (BAO) shows better outcomes than standard medical treatment (SMT). EVT is safe and feasible, offering improved functional outcomes and reduced mortality in BAO patients.
Area of Science:
- Neurology
- Interventional Cardiology
- Vascular Surgery
Background:
- Distal basilar artery occlusion (BAO) presents significant clinical challenges.
- Comparing endovascular treatment (EVT) with standard medical treatment (SMT) is crucial for optimizing patient care.
Purpose of the Study:
- To investigate and compare the clinical outcomes of EVT versus SMT for distal BAO.
- To evaluate the safety and efficacy of EVT in a real-world clinical setting.
Main Methods:
- Analysis of 267 patients with distal BAO from the BASILAR study (Jan 2014-May 2019).
- Comparison of outcomes between the EVT (n=222) and SMT (n=45) groups.
- Clinical outcomes assessed by modified Rankin Scale (mRS) at 90 days, 90-day mortality, and symptomatic intracranial hemorrhage.
Main Results:
- EVT group showed significantly higher favorable outcomes (mRS 0-3; 40.1% vs. 15.6%; aOR 5.44; P=0.005).
- EVT group had decreased 90-day mortality (44.6% vs. 71.1%; aOR 0.32; P=0.012).
- Initial NIHSS and pc-ASPECTS scores predicted outcomes in the EVT group.
Conclusions:
- EVT is technically feasible and safe for treating distal BAO.
- EVT offers superior clinical outcomes and reduced mortality compared to SMT for distal BAO.
Background:
This study aimed to investigate the clinical outcomes of endovascular treatment (EVT) for distal basilar artery occlusion (BAO) and compare them with the outcomes of standard medical treatment (SMT) in daily clinical practice.
Methods:
Patients with distal BAO enrolled in the BASILAR study from January 2014 to May 2019 were included. Differences in clinical outcomes were analyzed using Pearson's chi-square test and multivariable logistic regression. Clinical outcomes were evaluated using the modified Rankin Scale (mRS) score at 90 days, the mortality at 90 days, and the occurrence of symptomatic intracranial hemorrhage within 48 h.
Results:
Among the 267 patients with distal BAO (222 patients in the EVT group and 45 patients in the SMT group), compared with the SMT group, the EVT group was associated with a favorable outcome (mRS 0-3; 40.1 vs. 15.6%; aOR 5.44; 95% CI, 1.68-17.66; P = 0.005) and decreased mortality (44.6 vs. 71.1%, aOR 0.32, 95% CI, 0.13-0.77; P = 0.012). In the EVT group, multivariable analysis showed that the initial National Institutes of Health Stroke Scale (NIHSS) score and posterior circulation-Alberta Stroke Program Early CT Score (pc-ASPECTS) were associated with favorable functional outcomes and mortality.
Conclusion:
Our study suggests that, compared with SMT, EVT is technically feasible and safe for patients with distal BAO.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
01:27Peripheral Artery Disease III: Interprofessional Care