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Updated: Aug 30, 2025

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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KIF11 Is a Promising Therapeutic Target for Thyroid Cancer Treatment

Yue Han1, Jing Chen2, Dianjun Wei3

  • 1Department of Clinical Laboratory, The Secondary Hospital of Tianjin Medical University, Tianjin, China.

Computational and Mathematical Methods in Medicine
|August 26, 2022
PubMed
Abstract

Insights

Kinesin family member 11 (KIF11) is highly expressed in thyroid tumors and promotes cancer progression. KIF11 knockdown inhibits thyroid cancer cell proliferation and induces apoptosis, suggesting its role in tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology

Background:

  • Thyroid cancer is a significant global health concern.
  • Understanding the molecular mechanisms driving thyroid cancer progression is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the expression levels of KIF11 in human thyroid tumor tissues.
  • To evaluate the role of KIF11 in thyroid cancer cell proliferation, apoptosis, and tumor growth.

Main Methods:

  • Immunohistochemistry (IHC) was used to detect KIF11 expression in 71 thyroid carcinoma cases.
  • In vitro assays (colony formation, MTT, FCM) assessed KIF11's effects on cell proliferation and apoptosis.
  • An animal model was utilized to evaluate KIF11's impact on tumor growth.

Main Results:

  • Significantly elevated KIF11 expression was observed in thyroid tumor tissues.
  • KIF11 expression correlated with clinical pathological features, including T stage and intraglandular dissemination.
  • KIF11 knockdown suppressed thyroid cancer cell proliferation and induced apoptosis.
  • KIF11 contributed to tumor growth in a mouse model.

Conclusions:

  • KIF11 plays a significant role in the progression of thyroid cancer.
  • Targeting KIF11 may represent a potential therapeutic strategy for thyroid cancer.

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