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Updated: Aug 30, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Emerging roles for G-quadruplexes in proteostasis
Bryan B Guzman1, Ahyun Son2, Theodore J Litberg2
1Department of Pharmacology, University of North Carolina at Chapel Hill, NC, USA.
Abstract:
How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still-evolving area of research. Considerable effort is now focusing on a particular structure of RNA and DNA, G-quadruplexes, and their role in protein homeostasis and disease. In this state-of-the-art review, we track recent reports on how G-quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and pose currently unanswered questions in the advance of this scientific field.
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