Efficacy of Adjunctives in Periodontal Surgeries: An Evidenced-Based Summary

Periodontal surgery is required to access the root surfaces in order to debride them of dental plaque and calculus, promote pocket reduction, create healthy bone architecture, and provide patients greater access to out-of-reach areas to maintain oral hygiene. The use of adjunctive agents and materials-enamel matrix derivatives, low-laser treatment, ozone, locally administered minocycline HCL, doxycycline gels, tetracycline fibers, chlorhexidine chips, granular beta-tricalcium phosphate, and hyaluronic acid, and the like-have been reported to improve pocket depth reduction, periodontal ligament healing, bone defect filling, and mechanical debridement during guided tissue regeneration/flap surgeries. However, the efficacy and benefits of these adjuvants compared to periodontal surgery alone is still widely debated. This evidence-based review critically evaluates and summarizes the efficacy of adjuvants used in periodontal surgery that have been reported in the literature.