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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

50
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Related Experiment Video

Updated: Aug 30, 2025

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Expanded Criteria Donors.

Hassan Argani1

  • 1From the Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation
|August 26, 2022
PubMed
Summary

Expanded criteria donor kidneys, while having uncertain risks, can significantly reduce transplant wait times. Transplant recipients show higher survival rates compared to those on the waitlist, especially with perfusion pump use.

Area of Science:

  • Nephrology and Transplant Surgery
  • Organ Donation and Transplantation

Background:

  • Expanded criteria donors (ECD) are defined by age (>60) or younger donors (>50) with specific risk factors (hypertension, elevated creatinine, stroke death).
  • Utilizing ECD kidneys can shorten transplant waiting lists but requires informed consent due to potentially shorter graft survival.
  • The exact risks associated with ECD kidneys are not fully understood, though outcomes are generally less predictable than standard criteria donors.

Purpose of the Study:

  • To evaluate the outcomes and viability of using expanded criteria donor kidneys in transplantation.
  • To explore strategies for maximizing the utilization of the donor organ pool, including dual-kidney transplantation.
  • To assess the role of perfusion pump technology in assessing and preserving ECD kidneys.

Main Methods:

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248
  • Analysis of outcomes for recipients of expanded criteria donor kidneys compared to standard criteria donors and waitlisted candidates.
  • Investigation into the use of dual-kidney transplantation for ECD organs with insufficient single-kidney function.
  • Assessment of the impact of perfusion pump preservation on ECD kidney viability and clinical decision-making.

Main Results:

  • At 5-year follow-up, 50% of expanded criteria donor kidneys remain functional.
  • Transplant recipients, regardless of donor type, demonstrate superior survival rates compared to waitlisted patients.
  • Dual-kidney transplantation with ECD organs provides outcomes comparable to single-kidney transplants with normal function.

Conclusions:

  • Expanded criteria donor kidneys offer a viable option to increase organ availability and improve transplant recipient survival.
  • Perfusion pump technology aids in the assessment and selection of ECD kidneys, potentially increasing success rates.
  • Meticulous donor selection and advanced surgical techniques, including dual transplantation, can effectively expand the donor pool and address organ shortages.