Related Experiment Video
Updated: Aug 30, 2025
09:51
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
12.5K
Usage of Nanoparticles to Alter Neutrophils' Function for Therapy
Jing Wang1, Wenjun Le2, Tinghua Yan3
1Institute for Regenerative Medicine, Shanghai East Hospital, The Institute for Biomedical Engineering & Nano Science, Tongji University School of Medicine, Shanghai 200092, China.
ACS Biomaterials Science & Engineering
|August 26, 2022
Summary
Neutrophils, key immune cells, guide nanomaterials to inflammation sites via chemotaxis. Nanomaterials also modulate neutrophil function to treat tissue damage, offering new therapeutic strategies.
Area of Science:
- Immunology and Nanomedicine
Background:
- Neutrophils are crucial innate immune cells involved in inflammatory responses.
- Their chemotaxis enables migration to sites like tumors and infections.
- Aberrant neutrophil accumulation can cause tissue damage.
Purpose of the Study:
- To review the interactions between nanomaterials and neutrophils.
- To explore applications of neutrophil-based and neutrophil-interfering nanomaterials.
Main Methods:
- Literature review focusing on nanomaterial-neutrophil interactions.
- Analysis of neutrophil-based nanomaterials (composites, membrane-based).
- Examination of nanomaterials that interfere with neutrophil function.
Main Results:
- Neutrophil-based nanomaterials leverage chemotaxis for targeted drug/imaging agent delivery.
- Nanomaterials can be designed to inhibit neutrophil function, mitigating tissue damage.
- Understanding these interactions is key for therapeutic development.
Conclusions:
- Neutrophil-nanomaterial interactions offer dual therapeutic potential: targeted delivery and functional modulation.
- Future research can harness these interactions for advanced nanomedicine applications.
- This review highlights the significance of neutrophils in nanomedicine strategies.
