Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

225
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
225
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

401
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
401
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

827
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
827
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

59
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
59
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

650
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
650
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

397
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
397

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Nutrigenetic Markers Related to Nutrient Metabolism, Recovery, and Performance in Athletes: a Review of Current Evidence.

Current nutrition reports·2026
Same journal

Effect of Probiotics on the Gut-Mammary Pathway: Implications on Infant Microbiota Transfer and Development.

Current nutrition reports·2026
Same journal

From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making.

Current nutrition reports·2026
Same journal

Epigenetic Regulations by Olive Bioactives: Targeting HDAC for Disease Prevention and Therapy.

Current nutrition reports·2026
Same journal

Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.

Current nutrition reports·2026
Same journal

GLP-1 Receptor Agonists for Obesity Management in Older Adults: A Scoping Review on the Risk of Sarcopenia and Sarcopenic Obesity.

Current nutrition reports·2026

Related Experiment Video

Updated: Aug 30, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.3K

Diet, Gut Microbiome, and Cognitive Decline.

Susan Ettinger1

  • 1Interdisciplinary Health Sciences, New York Institute of Technology, New York, USA. ettingersusan64@gmail.com.

Current Nutrition Reports
|August 26, 2022
PubMed
Summary

Diet significantly impacts cognitive health by influencing the gut microbiota. Modulating gut bacteria through dietary choices may offer a strategy to combat age-associated cognitive decline and neurodegenerative diseases like Alzheimer's.

Keywords:
Alzheimer’s diseaseAmyloidCopperDysbiosisFlavonoidsFolateFructoseGut microbiomeGut-brain-axis signalingHomocysteineHormesisHydrogen sulfide donorsKetonesNADPolyphenolsTranssulfuration pathwayVitamin B12Vitamin B6

More Related Videos

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

10.9K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K

Related Experiment Videos

Last Updated: Aug 30, 2025

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice
07:49

Intracerebroventricular Delivery of Gut-Derived Microbial Metabolites in Freely Moving Mice

Published on: June 2, 2022

3.3K
Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
09:10

Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents

Published on: November 1, 2019

10.9K
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.7K

Area of Science:

  • Neuroscience
  • Microbiology
  • Nutrition Science

Background:

  • Age-associated cognitive decline, including Alzheimer's and Parkinson's disease, presents a growing public health challenge.
  • While genetic factors play a role, modifiable risk factors are increasingly recognized in sporadic cases.
  • The gut microbiota plays a crucial role in mediating the effects of diet on brain health.

Purpose of the Study:

  • To explore the intricate relationship between diet, gut microbiota, and cognitive function.
  • To highlight mechanisms by which dietary interventions can influence brain integrity.
  • To emphasize the role of these interactions in Alzheimer's disease pathogenesis.

Main Methods:

  • Review of scientific literature on diet, gut-brain axis, and neurodegeneration.
  • Analysis of microbial signaling pathways influenced by food components.
  • Examination of how gut barrier integrity and immune modulation relate to cognitive health.

Main Results:

  • Dietary components profoundly alter gut microbial composition and function.
  • Gut microbes produce metabolites that influence brain signaling and inflammation.
  • Modulation of the gut microbiota by diet impacts the integrity of the gut barrier and systemic immunity.

Conclusions:

  • Diet is a critical modifiable factor influencing cognitive decline.
  • Targeting the gut microbiota through dietary strategies holds potential for preventing or managing neurodegenerative diseases.
  • Understanding the diet-microbiota-brain axis is essential for developing novel therapeutic approaches.