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Effects of ECT given two vs. three times weekly.

D A McAllister, M G Perri, R C Jordan

Psychiatry Research

|May 1, 1987

Summary

Electroconvulsive therapy (ECT) effectively treats depression. Twice-weekly ECT showed similar symptom improvement to thrice-weekly sessions but with less visual memory impairment.

Area of Science:

Psychiatry
Neurology
Clinical Psychology

Background:

Electroconvulsive therapy (ECT) is a recognized treatment for severe depression.
Optimizing ECT frequency is crucial for balancing efficacy and cognitive side effects.

Purpose of the Study:

To compare the efficacy and side effects of twice-weekly versus thrice-weekly unilateral electroconvulsive therapy (ECT) in depressed inpatients.
To assess the impact of ECT frequency on psychiatric symptomatology and cognitive function, specifically memory.

Main Methods:

Twenty inpatients with depression were randomized to receive either twice-weekly or thrice-weekly unilateral ECT.
Assessments included clinician-rated depression and psychiatric status, self-rated depression, and tests of memory and visual-motor skills, conducted pre-treatment and at 2 and 4 weeks post-treatment.

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Main Results:

Both ECT schedules resulted in significant and comparable improvements in psychiatric symptoms.
Patients receiving twice-weekly ECT experienced significantly less visual memory impairment compared to those receiving thrice-weekly ECT.

Conclusions:

Twice-weekly unilateral ECT is as effective as thrice-weekly ECT for improving depressive symptoms.
A less frequent ECT schedule may mitigate cognitive side effects, particularly visual memory deficits.