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Memory and ventricular size in alcoholics.

C Acker, R R Jacobson, W A Lishman

    Psychological Medicine
    |May 1, 1987
    PubMed
    Summary
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    Chronic alcoholism impacts male memory, particularly verbal recall, correlating with third ventricle size on CT scans. Controls showed similar associations between verbal memory and CT measures.

    Area of Science:

    • Neuroscience
    • Radiology

    Background:

    • Chronic alcoholism is associated with cognitive deficits.
    • Cerebral ventricular enlargement, particularly the third ventricle, is a known consequence of alcoholism.

    Purpose of the Study:

    • To investigate the relationship between memory performance and cerebral ventricular size in chronic alcoholics and controls.
    • To determine if specific memory domains are differentially affected by ventricular size.

    Main Methods:

    • Computed tomography (CT) scans were used to measure lateral and third ventricular size.
    • Memory performance was assessed using tests of verbal, non-verbal, recognition, and recall memory.
    • A sample of 39 male chronic alcoholics and 39 age-matched male controls was studied.

    Main Results:

    Related Experiment Videos

    • Male alcoholics showed a significant relationship between memory performance and third ventricular size.
    • No significant relationship was found between memory performance and lateral ventricular size in male alcoholics.
    • Male controls exhibited an association between verbal memory performance and CT scan measures of ventricular size.

    Conclusions:

    • Third ventricular enlargement in male alcoholics is linked to impaired memory function, especially verbal recall.
    • Cerebral ventricular size, particularly the third ventricle, may serve as a biomarker for cognitive deficits in chronic alcoholism.