Acetabular protrusion in the Marfan syndrome

Area of Science:

• Medical Genetics
• Orthopedics
• Connective Tissue Diseases

Background:

• Marfan syndrome is a genetic disorder affecting connective tissues.
• It commonly leads to deformities in the eyes, cardiovascular system, and musculoskeletal system.

Purpose of the Study:

• To investigate the prevalence of acetabular protrusion in patients with Marfan syndrome.
• To determine the association between acetabular protrusion and scoliosis in this population.

Main Methods:

• Retrospective review of 22 cases diagnosed with Marfan syndrome.
• Analysis of skeletal findings, specifically acetabular protrusion and scoliosis.

Main Results:

• Acetabular protrusion was observed in 45% (10 of 22) of patients.
• Of those with acetabular protrusion, 90% (9 of 10) also had scoliosis.
• Acetabular protrusion occurred unilaterally and bilaterally in equal measure.

Conclusions:

• Acetabular protrusion is a frequent skeletal manifestation in Marfan syndrome.
• Scoliosis is highly associated with acetabular protrusion in Marfan syndrome patients.