Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decreased dopamine level in the epileptic focus.

A Mori, M Hiramatsu, S Namba

    Research Communications in Chemical Pathology and Pharmacology
    |May 1, 1987
    PubMed
    Summary

    Dopamine levels were significantly lower in the brain

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field.

    FEBS letters·1995
    Same author

    Adenosines scavenged hydroxyl radicals and prevented posttraumatic epilepsy.

    Free radical biology & medicine·1995
    Same author

    Myofibroma of the mandible. Clinicopathologic study and review of the literature.

    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1995
    Same author

    A transcription terminator signal necessary for plasmid ColIb-P9 replication.

    Molecular microbiology·1995
    Same author

    [Pharmacokinetic and clinical studies of S-1108 in the pediatric field. Pediatric Study Group of S-1108].

    The Japanese journal of antibiotics·1995
    Same author

    The complete amino acid sequence of lectin-C from the roots of pokeweed (Phytolacca americana).

    Bioscience, biotechnology, and biochemistry·1995

    Area of Science:

    • Neuroscience
    • Biochemistry

    Background:

    • Epilepsy is a neurological disorder characterized by recurrent seizures.
    • Neurotransmitter imbalances, including catecholamines and serotonin, are implicated in epilepsy pathophysiology.

    Purpose of the Study:

    • To investigate catecholamine and serotonin levels in the epileptic foci of patients with intractable epilepsy.
    • To compare neurotransmitter levels in epileptic tissue with surrounding healthy tissue and non-convulsive neuropathic patients.

    Main Methods:

    • Analysis of catecholamine and serotonin in surgical tissue samples from 12 intractable epilepsy patients.
    • High-performance liquid chromatography with electrochemical detection (HPLC-ECD) was employed for precise quantification.

    Main Results:

    • Significantly lower dopamine concentrations were observed in the epileptic foci compared to surrounding tissues in 7 out of 12 patients.
    • The remaining 5 patients also exhibited markedly reduced dopamine levels when compared to non-convulsive neuropathic controls.
    • No specific findings were mentioned for serotonin in the provided abstract.

    Conclusions:

    • Reduced dopamine levels in epileptic foci may play a role in the pathophysiology of intractable epilepsy.
    • Dopamine deficiency could be a contributing factor to seizure generation or maintenance in these patients.

    Related Experiment Videos