Related Experiment Video
Updated: Aug 30, 2025
Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
Published on: February 8, 2017
Risk Factors of Second Local Recurrence in Surgically Treated Recurrent Brain Metastases: An Exploratory Analysis
Ishaan Ashwini Tewarie1, Alexander F C Hulsbergen1, Charissa A C Jessurun1
1Computational Neurosciences Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Neurosurgery, Leiden University Medical Center, Leiden, The Netherlands; School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, Boston, Massachusetts, USA; Department of Neurosurgery, Haaglanden Medical Center, The Hague, The Netherlands.
Second local recurrences of brain metastases (BM) after initial surgery are common. Subtotal resection and infratentorial location predict a worse prognosis for these recurrent brain metastases.
Area of Science:
- Neurosurgery
- Oncology
- Radiotherapy
Background:
- First local recurrence of brain metastases (BM) is frequent after resection or radiotherapy.
- Data on second local recurrences of BM are limited.
- This study investigates predictors of second local recurrence after craniotomy for first recurrent BM.
Purpose of the Study:
- To identify predictors associated with a second local recurrence in patients with BM.
- To analyze outcomes following surgical treatment of first recurrent BM.
Main Methods:
- Retrospective analysis of patients from Brigham and Women's Hospital database.
- Cox proportional hazards model used to compute hazard ratios and confidence intervals for predictors.
- Identified 170 surgically treated first locally recurrent BM lesions.
Main Results:
- 43.5% of patients developed a second local recurrence at a median of 7 months post-craniotomy.
- Subtotal resection of the first local BM recurrence was significantly associated with a shorter time to second local recurrence (HR=2.09).
- Infratentorial location was associated with a worse prognosis for second local recurrence (HR=2.22).
Conclusions:
- Second local recurrence occurred in 43.5% of cases after craniotomy for first recurrent BM.
- Subtotal resection and infratentorial location are significant risk factors for worse prognosis.
- These findings highlight critical factors influencing outcomes in patients with recurrent brain metastases.
