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Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
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Modeling a 3-D multiscale blood-flow and heat-transfer framework for realistic vascular systems.

Rohan Amare1,2, Erlend Hodneland3,4, Jeremy A Roberts5

  • 1Institute for Environmental Research, Kansas State University, Manhattan, KS, USA. amarerohan@ksu.edu.

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This study introduces a Voxelized Multi-Physics Simulation (VoM-PhyS) framework for modeling blood flow and heat transfer in biological tissues. The VoM-PhyS framework accurately simulates complex vascular networks and their thermal properties.

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Area of Science:

  • Computational biology
  • Biophysics
  • Medical physics

Background:

  • Modeling complex biological systems, like human vasculature, is challenging due to intricate branching and dimensional variations.
  • Accurate simulation of biophysical processes is crucial for informing medical procedures and understanding physiological phenomena.

Purpose of the Study:

  • To present a novel Voxelized Multi-Physics Simulation (VoM-PhyS) framework for simulating coupled heat transfer and fluid flow in biological domains.
  • To address the challenges of modeling complex blood vessel networks and their impact on thermo-physiological processes.

Main Methods:

  • Developed a multi-scale voxel mesh for biological domains.
  • Modeled 1D flow in larger vessels using Hagen-Poiseuille and 3D porous media for capillaries.
  • Utilized the Dirac distribution function as a Sphere of Influence (SoI) to couple flow models.
  • Integrated a heat transfer solver for comprehensive thermo-physiological simulation.

Main Results:

  • Demonstrated the VoM-PhyS framework on a frog tongue model.
  • Analyzed the impact of convective heat exchange between blood vessels and tissue.
  • Investigated the influence of the Sphere of Influence (SoI) parameter on simulation outcomes.

Conclusions:

  • The VoM-PhyS framework provides a robust method for simulating coupled fluid flow and heat transfer in complex biological vasculature.
  • The study highlights the importance of considering convective heat exchange and SoI effects for accurate physiological simulations.