Intragastric bile acid concentrations in patients with erosive prepyloric changes

In the search for pathogenetic mechanisms behind EPC, intragastric bile acids were measured in 60 patients with non-ulcer dyspepsia (NUD) and grade 2 or 3 erosive prepyloric changes (EPC) and in 20 control subjects. Intragastric bile acid concentrations tended to be higher in the control subjects than in the EPC patients, but the difference did not reach statistical significance. The results neither support nor disprove the hypothesis that bile acid-induced mucosal damage may be involved in the pathogenesis of EPC.