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Published on: January 14, 2014
Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study
Lisa Millgård Sagberg1,2, Even Hovig Fyllingen3,4, Tor Ivar Hansen5,6
1Department of Neurosurgery, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. lisa.millgard.sagberg@ntnu.no.
Purpose:
Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of IDH-mutant low-grade glioma.
Methods:
In a multicenter case-control study based on population-based data, we included 154 patients with IDH-mutant WHO grade 2 glioma and 995 healthy controls. ICV in both groups was calculated from 3D MRI brain scans using an automated reverse brain mask method, and then compared using a binomial logistic regression model.
Results:
We found a non-linear association between ICV and risk of glioma with increasing risk above and below a threshold of 1394 ml (p < 0.001). After adjusting for ICV, sex was not a risk factor for glioma.
Conclusion:
Intracranial volume may be a risk factor for IDH-mutant low-grade glioma, but the relationship seems to be non-linear with increased risk both above and below a threshold in intracranial volume.
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