Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

681
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
681
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

359
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
359
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

7.0K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
7.0K
Neural Regulation01:37

Neural Regulation

39.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.7K
Phosphorylation01:02

Phosphorylation

50.9K
The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
During phosphorylation, protein kinases transfer the terminal phosphate group of ATP to specific amino acid side chains of substrate proteins. Serine, threonine, and tyrosine are the most commonly...
50.9K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.9K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interregional human assembloids recapitulate fetal brain morphologies and enhance neuronal complexity.

bioRxiv : the preprint server for biology·2025
Same author

Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders.

Frontiers in neuroscience·2024
Same author

Impact of Microbiota Depletion by Antibiotics on SARS-CoV-2 Infection of K18-hACE2 Mice.

Cells·2022
Same author

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Evaluation of the association of the Renalase rs10887800 polymorphism with the risk of preeclampsia in Brazilian women.

Pregnancy hypertension·2022
Same author

Application of a cost-effective DNA extraction protocol for screening transgenic and CRISPR-edited primary goat cells.

PloS one·2020

Related Experiment Video

Updated: Aug 30, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

7.6K

Post-translational Modifications in Parkinson's Disease.

André Saraiva Leão Marcelo Antunes1

  • 1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), São Paulo, Brazil. aslmantunes@gmail.com.

Advances in Experimental Medicine and Biology
|August 27, 2022
PubMed
Summary

Parkinson's disease (PD) involves the loss of specific neurons. This chapter explores how protein post-translational modifications impact PD, offering insights into disease mechanisms and potential therapeutic targets.

Keywords:
Mass spectrometryParkinson's diseasePost translation modifications

More Related Videos

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.0K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.6K

Related Experiment Videos

Last Updated: Aug 30, 2025

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models
08:33

Characterizing Histone Post-translational Modification Alterations in Yeast Neurodegenerative Proteinopathy Models

Published on: March 24, 2019

7.6K
Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration
07:46

Gait Analysis of Age-dependent Motor Impairments in Mice with Neurodegeneration

Published on: June 18, 2018

12.0K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.6K

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder causing motor deficits due to dopaminergic neuron loss.
  • The exact cause of PD is unknown, with sporadic cases comprising 90% of diagnoses.
  • Genetic factors, including alpha-synuclein and mitochondrial genes, are implicated in inherited PD.

Purpose of the Study:

  • To review the significance of protein post-translational modifications (PTMs) in Parkinson's disease.
  • To outline methods for studying PTMs in the context of PD.
  • To elucidate how PTMs influence proteins relevant to PD pathogenesis.

Main Methods:

  • Literature review of PTMs in neurodegenerative diseases.
  • Analysis of studies investigating protein modifications in Parkinson's disease.
  • Discussion of techniques used to identify and analyze PTMs.

Main Results:

  • PTMs dynamically regulate protein function and cellular signaling networks.
  • Specific PTMs have been identified in proteins associated with PD pathology.
  • Understanding PTMs provides insights into the complex molecular mechanisms underlying PD.

Conclusions:

  • PTMs play a crucial role in the development and progression of Parkinson's disease.
  • Further research into PTMs may reveal novel diagnostic markers and therapeutic strategies for PD.
  • Investigating PTMs is essential for a comprehensive understanding of PD etiology.