Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

133
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
133
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

179
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
179
Human Genetics01:28

Human Genetics

694
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
694
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

908
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
908
Biological Influences on Intelligence01:30

Biological Influences on Intelligence

189
Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter...
189
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

115
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
115

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune, Developmental, and Synaptic Pathways Define Bipolar Disorder Clinical Heterogeneity.

medRxiv : the preprint server for health sciences·2025
Same author

Genomics yields biological and phenotypic insights into bipolar disorder.

Nature·2025
Same author

A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics·2023
Same author

Sensitivity of Schizophrenia Endophenotype Biomarkers to Anticholinergic Medication Burden.

The American journal of psychiatry·2023
Same author

Bipolar spectrum traits and the space between Madness and Genius: The Muse is in the Dose.

Journal of psychiatric research·2022
Same author

Mapping genomic loci implicates genes and synaptic biology in schizophrenia.

Nature·2022

Related Experiment Video

Updated: Aug 30, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K

Genetic Influences on Cognitive Dysfunction in Schizophrenia.

Tiffany A Greenwood1

  • 1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. tgreenwood@ucsd.edu.

Current Topics in Behavioral Neurosciences
|August 27, 2022
PubMed
Summary

Understanding cognitive dysfunction in schizophrenia is key to uncovering genetic risk factors. Quantitative measures offer a more efficient approach to identify genetic variants and develop targeted treatments.

Keywords:
CognitionEndophenotypeGeneticsSchizophrenia

More Related Videos

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.6K

Related Experiment Videos

Last Updated: Aug 30, 2025

Development of a Virtual Reality Assessment of Everyday Living Skills
10:32

Development of a Virtual Reality Assessment of Everyday Living Skills

Published on: April 23, 2014

18.6K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.0K
Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells
08:04

Derivation, Expansion, Cryopreservation and Characterization of Brain Microvascular Endothelial Cells from Human Induced Pluripotent Stem Cells

Published on: November 19, 2020

6.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Schizophrenia is a highly heritable psychotic disorder with significant clinical heterogeneity.
  • Current genomic studies often overlook genetic risk in unaffected individuals and lack biological insight into symptom pathways.
  • Cognitive dysfunction is a core symptom impacting quality of life and functional outcomes in schizophrenia.

Purpose of the Study:

  • To evaluate the utility of quantitative cognitive measures for identifying neurobiological pathways and genetic variants in schizophrenia.
  • To explore how objective cognitive assessments can supplement traditional diagnostic approaches in genetic research.
  • To facilitate the translation of genetic findings into targeted therapeutic interventions for schizophrenia.

Main Methods:

  • Utilizing quantitative measures of cognitive dysfunction as a research tool.
  • Supplementing traditional case-control genomic analyses with a focus on specific phenotypes.
  • Analyzing genetic variants and gene networks associated with cognitive deficits.

Main Results:

  • Quantitative measures provide a more efficient method for identifying genetic variants associated with complex disorders like schizophrenia.
  • This approach aids in understanding the genetic architecture and biological pathways underlying schizophrenia.
  • Objective cognitive data can help bridge the gap between genetic discoveries and clinical applications.

Conclusions:

  • Focusing on cognitive dysfunction offers a biologically relevant approach to schizophrenia research.
  • Quantitative cognitive assessments enhance the efficiency and biological insight of genetic studies.
  • Understanding the genetic basis of cognitive deficits can drive the development of new pharmacological and procognitive treatments for schizophrenia.