Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Aging01:26

Aging

163
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
163
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

36.7K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
36.7K
Mitochondria01:37

Mitochondria

14.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating air pollution and economic impacts in Chinese megacity clusters under clean air policies.

iScience·2026
Same author

How stratospheric intrusion modulates the optimal mitigation pathway for ozone under sharp emission reductions.

Ecotoxicology and environmental safety·2026
Same author

Targeting Pyruvate Kinase M2: Signal Transduction Pathways and Exploration of Cancer Therapeutic Strategies.

The AAPS journal·2026
Same author

Natural Products Beyond Inhibition: A Mechanistic Framework Spanning Pockets, Interfaces, and Kinetic Barriers.

Molecules (Basel, Switzerland)·2026
Same author

Unraveling the pleiotropic effects of CCR2-dependent signal transduction in fibrosis development.

Theranostics·2026
Same author

Physicochemical, structural, digestive stability, and microbiota effects of five edible mushroom polysaccharides (EMPs).

International journal of biological macromolecules·2026

Related Experiment Video

Updated: Aug 30, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K

Deciphering clock genes as emerging targets against aging.

Yanli Zhu1, Yanqing Liu1, Germaine Escames2

  • 1Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.

Ageing Research Reviews
|August 27, 2022
PubMed
Summary

Disturbances in circadian rhythm accelerate aging and are linked to degenerative diseases. Clock genes are crucial regulators of this rhythm and aging processes, offering potential anti-aging therapeutic targets.

Keywords:
AgingAlzheimer's diseaseClock genesGenetic polymorphismsOsteoarthritisParkinson's disease

More Related Videos

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Related Experiment Videos

Last Updated: Aug 30, 2025

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.4K

Area of Science:

  • Gerontology
  • Chronobiology
  • Molecular Biology

Background:

  • Aging is associated with circadian rhythm disturbances.
  • Circadian rhythm disruption accelerates aging and is linked to neurodegenerative and osteoarthritis diseases.
  • Clock genes are key regulators of circadian rhythms.

Purpose of the Study:

  • To systematically review the roles of clock genes in aging.
  • To explore the connection between clock genes, circadian rhythm, and aging-related diseases.
  • To discuss the potential of clock genes as anti-aging therapeutic targets.

Main Methods:

  • Literature review of clock gene functions in aging.
  • Systematic summary of clock gene roles in aging and related diseases.
  • Analysis of the relationship between clock gene polymorphisms and aging.

Main Results:

  • Clock genes play predominant roles in regulating circadian rhythm.
  • Clock gene dysregulation is implicated in accelerated aging and age-related diseases.
  • Clock gene polymorphisms are associated with aging processes.

Conclusions:

  • Clock genes are indispensable in regulating aging processes.
  • Understanding clock gene networks provides insights into aging mechanisms.
  • Targeting clock genes offers a promising strategy for anti-aging interventions.