Related Experiment Video
Updated: Aug 30, 2025
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
The difference of the retinal structural and microvascular characteristics in patients with MOGAD-ON and AQP4-ON
Yajun Yao1, Xindi Li1, Yun Xu1
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Background:
Antibodies against myelin-oligodendrocyte-glycoprotein (MOG-Abs) associated disease (MOGAD) has been recognized as a disease entity. Optic neuritis (ON) is the most common symptom in MOGAD. To demonstrate the differences in retinal microvascular characteristics between patients with MOGAD-ON and aquaporin-4 antibody (AQP4-Ab) positive ON.
Methods:
In a prospective study, optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) were used to measure retinal and microvascular parameters.
Results:
Twenty-six MOGAD-ON eyes, 40 AQP4-ON eyes, and 60 control eyes were included in the study. The thickness of RNFL and GCC in MOGAD-ON eyes was significantly lower than that of HC (p < 0.001, respectively), but comparable to AQP4-ON eyes. The vessel density in retina capillary plexus (RCP) was reduced significantly in MOGAD-ON than that in AQP4-ON (p < 0.05, respectively). The visual accuracy was positively correlated with vessel density of superficial RCP in MOG-ON (p = 0.001) and positively correlated with the thickness of the inner retina layer in AQP4-ON (p < 0.001).
Conclusion:
The retinal neuro-axonal damages between MOGAD-ON and AQP4-ON were comparable. Unlike AQP4-ON eyes, microvascular densities were significantly reduced in MOGAD-ON and were positively correlated with the deterioration of visual acuity in MOGAD-ON.
Trial Registration:
Clinical and Imaging Patterns of Neuroinflammation Diseases in China (CLUE, NCT: 04106830).
