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Long-term evolutionary adaptation of SIVcpz toward HIV-1 using a humanized mouse model
Kimberly Schmitt1, James Curlin1,2, Leila Remling-Mulder1
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, USA.
Journal of Medical Primatology
|August 28, 2022
Abstract:
Critical genetic adaptations needed for SIV chimpanzee to evolve into HIV-1 are not well understood. Using humanized mice, we mimicked the evolution of SIVcpzLB715 into HIV-1 Group M over the course of four generations. Higher initial viral load, increased CD4+ T-cell decline, and nonsynonymous substitutions arose suggesting viral evolution.
