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The role of transketolase in human cancer progression and therapy

Shiming Hao1, Qingfei Meng1, Huihui Sun1

  • 1Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 28, 2022
PubMed

Insights

Transketolase (TKT) and its related genes (TKTL1, TKTL2) are key regulators in cancer. Targeting TKT shows promise for cancer treatment and early detection, but its clinical application requires careful evaluation.

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Transketolase (TKT) is an enzyme crucial for cellular metabolism.
  • The TKT gene family, including TKTL1 and TKTL2, plays a significant role in cancer development and progression.
  • TKT and TKTL1 are implicated in various cancer hallmarks, including proliferation, metastasis, and treatment resistance.

Purpose of the Study:

  • To review the multifaceted roles of TKT in different cancer types.
  • To elucidate the mechanisms by which TKT influences cancer-related events.
  • To evaluate the clinical utility and limitations of TKT-targeted therapies and TKTL1 detection.

Main Methods:

  • Literature review of studies on TKT and its family members in cancer.
  • Analysis of TKT's involvement in cancer cell proliferation, metastasis, invasion, and epithelial-mesenchymal transition.
  • Examination of TKTL1's role in chemoradiotherapy resistance and patient prognosis.
  • Assessment of EDIM technology for TKTL1 detection in early cancer diagnosis and postsurgical evaluation.

Main Results:

  • TKT and TKTL1 are significantly involved in regulating cancer cell proliferation, metastasis, and invasion.
  • TKTL1 shows potential as a sensitive and specific biomarker for early cancer detection using EDIM technology.
  • Targeting TKT can suppress cancer growth but may also have detrimental effects.
  • TKTL1 levels can be used to monitor surgical treatment efficacy.

Conclusions:

  • TKT represents a promising therapeutic target for various cancers due to its regulatory roles in multiple cancer-related events.
  • TKTL1 holds significant potential for early cancer diagnosis and treatment monitoring.
  • Further research is needed to fully understand the clinical applications and limitations of TKT-targeted therapies.
Keywords:
Cancer treatmentMetabolismPentose phosphate pathwayTKTTumor progression

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