Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

111
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
111
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

79
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
79
Microbial Morphologies01:29

Microbial Morphologies

478
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
478
Prokaryotic Gene Structure and Organization01:28

Prokaryotic Gene Structure and Organization

403
Prokaryotic genomes exhibit a streamlined organization of coding and non-coding regions essential for gene expression and protein synthesis. While coding regions contain the genetic instructions for proteins or functional RNAs, non-coding regions regulate the precise transcription and translation of these genes.Coding Regions: Proteins and RNAsThe primary coding regions, known as structural genes, include sequences transcribed into messenger RNA (mRNA) and ultimately translated into...
403
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.1K
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

117
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
117

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

A phase-variable capsule facilitates <i>Akkermansia muciniphila</i> colonization of the intestinal mucus layer.

mBio·2026
Same author

Impact of stopping contact precautions on <i>vanA</i> plasmid transmission, Northern California, 2021-2023.

Antimicrobial stewardship & healthcare epidemiology : ASHE·2026
Same author

Participant engagement and feedback in microbiome projects: a case of AWI-Gen 2.

bioRxiv : the preprint server for biology·2026
Same author

Transposable elements are driving rapid adaptation of Enterococcus faecium.

Nature·2026
Same author

Implementation of wastewater-based epidemiology in a Northern California acute care hospital: a pilot study, June-July 2024.

The Journal of hospital infection·2026

Related Experiment Video

Updated: Aug 30, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.3K

From genome structure to function: insights into structural variation in microbiology.

Patrick T West1, Rachael B Chanin1, Ami S Bhatt1

  • 1Department of Genetics, Stanford University, 269 Campus Dr, CCSR 1155b, Stanford, 94305 CA, USA; Department of Medicine (Hematology, Blood and Marrow Transplantation), 269 Campus Dr, CCSR 1155b, Stanford, CA 94305, USA.

Current Opinion in Microbiology
|August 28, 2022
PubMed
Summary
This summary is machine-generated.

Bacterial genome structural variations drive evolution and adaptation. While understudied, new sequencing and bioinformatics tools promise deeper insights into microbial genomics.

More Related Videos

Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

6.3K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.0K

Related Experiment Videos

Last Updated: Aug 30, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.3K
Microbial Communities in Nature and Laboratory - Interview
29:13

Microbial Communities in Nature and Laboratory - Interview

Published on: May 28, 2007

6.3K
Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.0K

Area of Science:

  • Microbial genomics
  • Evolutionary biology
  • Bioinformatics

Background:

  • Structural variations, including inversions, duplications, and insertions, are key drivers of bacterial genome evolution.
  • These genomic rearrangements influence gene expression and facilitate adaptation to new environments.
  • Many structural variations are reversible, contributing to bacterial population heterogeneity.

Purpose of the Study:

  • To highlight the significance of structural variation in bacterial genomes.
  • To address the understudied nature of bacterial genomic variation compared to eukaryotes.
  • To emphasize the potential of recent technological advancements in microbial genomics.

Main Methods:

  • Review of existing literature on bacterial genome structural variation.
  • Discussion of advancements in genome sequencing technologies.
  • Exploration of new bioinformatic pipelines for variation detection.

Main Results:

  • Structural variations play a crucial role in bacterial adaptation and evolution.
  • There is a gap in the study of structural variation in bacteria and metagenomes compared to eukaryotes.
  • Emerging technologies and methods are improving the detection and analysis of these variations.

Conclusions:

  • Structural variations are fundamental to understanding bacterial evolution and adaptation.
  • Further research and technological development are needed to fully explore bacterial genomic variation.
  • Advancements in sequencing and bioinformatics are crucial for future discoveries in microbial genomics.