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Related Experiment Video

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Mapping grip-force related brain activity after a fatiguing motor task in multiple sclerosis.

Olivia Svolgaard1, Kasper Winther Andersen1, Christian Bauer2

  • 1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.

Neuroimage. Clinical
|August 28, 2022
PubMed
Summary

Motor fatigue in multiple sclerosis (MS) involves altered brain activity. Patients with MS show increased motor system engagement, and recruiting specific brain regions may protect against daily fatigue.

Keywords:
Functional magnetic resonance imagingGrip-force taskMotor fatigabilityMultiple sclerosisPremotor cortexPutamen

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Area of Science:

  • Neuroscience
  • Motor Control
  • Medical Imaging

Background:

  • Motor fatigue is a prevalent yet poorly understood symptom in multiple sclerosis (MS).
  • The underlying pathophysiology of motor fatigue in MS requires further investigation.
  • Functional magnetic resonance imaging (fMRI) can elucidate changes in motor system activity due to fatigue.

Purpose of the Study:

  • To investigate how acute motor fatigue induction alters functional activity within the motor system.
  • To determine the relationship between these activity changes and the experience of motor fatigue.
  • To compare brain activity patterns between MS patients and healthy controls during fatiguing tasks.

Main Methods:

  • Forty-four patients with relapsing-remitting MS and 25 healthy controls performed a maximal tonic precision grip task until fatigue.
  • fMRI at 3T was used to map task-related brain activity before and after the fatiguing task.
  • Statistical parametric mapping analyzed changes in activation from pre-fatigue to recovery phases.

Main Results:

  • Task performance was impaired post-fatigue in both groups, with increased ipsilateral primary motor hand area activation.
  • MS patients exhibited bilateral increases in middle putamen and lateral prefrontal cortex activity during recovery.
  • Greater recruitment of the left dorsal premotor cortex correlated with reduced self-reported daily motor fatigue in MS patients.

Conclusions:

  • Multiple sclerosis patients demonstrate heightened functional engagement of the cortico-basal ganglia loop after motor fatigue.
  • This enhanced activity may indicate increased cognitive effort required for movement post-fatigue.
  • Recruitment of the contralateral dorsal premotor cortex appears to be a protective mechanism against daily motor fatigue in MS.