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Real-World Treatment Patterns, Resource Use and Costs in Adult Patients With Atopic Dermatitis Receiving Systemic
Actas Dermo-Sifiliograficas
|August 28, 2022
Summary
Adults with moderate-severe atopic dermatitis (AD) experience significant burden, often requiring systemic treatments. This study highlights high comorbidity and costs, underscoring the need for effective AD therapies.
Area of Science:
- Dermatology
- Real-world evidence
- Health economics
Background:
- Moderate-to-severe atopic dermatitis (AD) significantly impacts patient quality of life.
- Systemic treatments and phototherapy are often necessary for managing AD symptoms.
- Real-world data on treatment patterns and costs in adult AD patients are limited.
Purpose of the Study:
- To describe sociodemographic and clinical characteristics of adults with AD initiating systemic treatment or phototherapy.
- To analyze treatment patterns, health resource utilization (HRU), and associated costs in routine practice.
- To identify unmet needs in the management of adult atopic dermatitis.
Main Methods:
- Retrospective observational study using the BIG-PAC database.
- Identified adults with AD (ICD-9: 691.8 or 692.9) initiating systemic therapy or phototherapy (2012-2016).
- Followed patients for 3 years, analyzing characteristics, treatments, HRU, and costs descriptively.
Main Results:
- 1995 adult patients (mean age 60) with a long disease duration (mean 23 years) were included.
- High comorbidity rates observed: anxiety (38%), hypertension (36%), dyslipidemia (35%).
- Oral corticosteroids were common first-line treatments (84%), with increasing use of immunosuppressants and biologics in subsequent lines; average 3-year cost was €3835 per patient.
Conclusions:
- Adult AD patients exhibit substantial comorbidity and economic burden.
- Treatment patterns indicate a need for more targeted and effective systemic therapies for AD.
- Real-world data support the necessity of approved systemic treatments for atopic dermatitis management.
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