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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.8K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Related Experiment Video

Updated: Aug 30, 2025

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

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An engineered dual function peptide to repair fractured bones.

Stewart A Low1, Jeffery J Nielsen2, Cheyanne M Coakley3

  • 1Department of Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 28, 2022
PubMed
Summary

A novel fracture-targeted peptide accelerates bone healing by over 50% and doubles bone strength. This targeted anabolic peptide shows no toxicity in dogs and holds promise for revolutionizing fracture treatment.

Keywords:
Anabolic peptideFracture healingPTHR1 receptorTargeted delivery

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Establishing a Diaphyseal Femur Fracture Model in Mice
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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
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Establishing a Diaphyseal Femur Fracture Model in Mice
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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Orthopedic Research

Background:

  • Fracture-associated morbidities pose a significant global health and economic burden.
  • Current fracture treatment methods have seen limited advancement.
  • Systemic delivery of bone anabolics offers a promising therapeutic strategy.

Purpose of the Study:

  • To design and evaluate a novel fracture-targeted peptide for enhanced bone repair.
  • To assess the efficacy and safety of this targeted delivery system.

Main Methods:

  • A peptide was engineered with a parathyroid hormone receptor (PTHR1) activating payload and a D-glutamic acid targeting ligand.
  • The peptide's accumulation at fracture sites was investigated.
  • Efficacy was tested in mice with standard, osteoporotic, and diabetic fractures.
  • Toxicity was evaluated in dogs.

Main Results:

  • The targeted peptide reduced fracture healing time by over 50% and increased repaired bone strength by more than 2-fold in mice.
  • The peptide demonstrated no detectable toxicity or adverse effects on healthy tissues or bones in dogs.
  • Similar positive outcomes were observed in osteoporotic and diabetic fracture models.
  • Simultaneous acceleration of pain resolution was noted.

Conclusions:

  • The developed fracture-targeted anabolic peptide significantly enhances bone fracture repair.
  • This targeted delivery system exhibits a favorable safety profile and broad applicability across different fracture types.
  • The peptide has the potential to revolutionize the treatment of bone fractures.