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Strongyloides meningitis.

A Belani, D Leptrone, J W Shands

    Southern Medical Journal
    |July 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    A woman on long-term steroids developed meningitis. Strongyloides stercoralis infection was diagnosed via larvae in stool, sputum, and cerebrospinal fluid, and successfully treated with thiabendazole.

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    Area of Science:

    • Infectious Diseases
    • Neurology
    • Parasitology

    Background:

    • Long-term steroid therapy can suppress immune function, increasing susceptibility to opportunistic infections.
    • Acute pyogenic meningitis is a serious condition often caused by bacterial or fungal pathogens.

    Observation:

    • A 46-year-old woman on long-term steroids presented with meningitis unresponsive to antibiotics.
    • Cultures for bacteria and fungi were negative.
    • Strongyloides stercoralis larvae were identified in stool, sputum, and cerebrospinal fluid.

    Findings:

    • The patient's meningitis was caused by Strongyloides stercoralis hyperinfection.
    • Treatment with thiabendazole effectively eradicated the parasite.
    • Cerebrospinal fluid abnormalities resolved following antiparasitic therapy.

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    Implications:

    • Strongyloides stercoralis should be considered in immunocompromised patients presenting with meningitis of unknown etiology.
    • Early diagnosis and treatment of strongyloidiasis are crucial to prevent severe complications.
    • Steroid-induced immunosuppression is a significant risk factor for hyperinfection syndrome.