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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood Transfusion01:15

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Updated: Aug 30, 2025

Microfluidics in Assessing Platelet Function
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Platelet transfusion in adults: An update.

O Garraud1, H Hamzeh-Cognasse1, E Chalayer2

  • 1SAINBIOSE, INSERM, U1059, University of Lyon, Saint-Étienne, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|August 28, 2022
PubMed
Summary

Platelet component (PC) transfusions are vital for treating bleeding risks but carry higher severe reaction rates than red blood cells. Optimizing PC transfusion practices enhances patient outcomes and safety.

Keywords:
Blood donationBlood safetyHemovigilanceInflammationPlatelet componentPlateletsSerious hazardsTransfusion

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Area of Science:

  • Transfusion Medicine
  • Hematology
  • Immunology

Background:

  • Platelet components (PCs) are crucial for managing thrombocytopenia and preventing severe bleeding.
  • Despite leukoreduction, PC transfusions have significantly higher severe reaction rates compared to red blood cell transfusions.
  • PC quality is affected by donor variability, collection/preparation methods, safety measures, and storage, leading to "storage lesions".

Purpose of the Study:

  • To provide a comprehensive overview of platelet transfusion.
  • To examine factors influencing PC efficacy and safety from donation to transfusion.
  • To discuss strategies for improving transfusion outcomes and explore alternatives to PC transfusion.

Main Methods:

  • Literature review of platelet transfusion practices.
  • Analysis of factors affecting platelet component quality and patient outcomes.
  • Examination of antigen matching and adverse reaction mitigation strategies.

Main Results:

  • Platelet transfusions are associated with substantial severe adverse reactions.
  • Donor, collection, preparation, and storage methods impact PC quality and efficacy.
  • Good transfusion practices, including antigen matching, improve platelet recovery and reduce complications.

Conclusions:

  • Optimizing platelet transfusion practices is essential for improving patient outcomes.
  • Addressing "storage lesions" and implementing appropriate antigen matching can enhance transfusion efficacy and safety.
  • Further research into alternatives to platelet transfusion may be warranted.