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Updated: Aug 30, 2025

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Functional and Morphological Assessment of Diaphragm Innervation by Phrenic Motor Neurons
Published on: May 25, 2015
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Phrenic nerve paralysis and phrenic nerve reconstruction surgery.
Matthew R Kaufman1, Nicole Ferro2, Ethan Paulin2
1Institute for Advanced Reconstruction, Shrewsbury, NJ, United States; Division of Plastic and Reconstructive Surgery, UCLA Medical Center, Los Angeles, CA, United States.
Handbook of Clinical Neurology
|August 28, 2022
Summary
Phrenic nerve injury causes diaphragm paralysis, impacting breathing and posture. Surgical reconstruction offers a safe, effective treatment for selected patients, improving outcomes.
Area of Science:
- Neurology
- Pulmonology
- Surgical Innovation
Background:
- Phrenic nerve injury leads to diaphragm paralysis, affecting respiration, posture, and spinal alignment.
- Symptoms range from exertional dyspnea to ventilator dependency, with common causes including trauma and iatrogenic injury.
- Idiopathic paralysis is frequent, highlighting the need for accurate diagnosis and effective treatments.
Purpose of the Study:
- To review the diagnostic evaluation and treatment options for diaphragm paralysis.
- To highlight phrenic nerve reconstruction as a viable surgical alternative to diaphragm plication.
- To emphasize the importance of a multidisciplinary approach for optimal patient outcomes.
Main Methods:
- Diagnostic evaluation involves radiographic, pulmonary function, and electrodiagnostic testing.
- Treatment options include medical management, positive airway pressure, and surgical interventions.
- Phrenic nerve reconstruction is detailed as a primary surgical approach for selected patients.
Main Results:
- Phrenic nerve reconstruction is a safe and effective treatment for diaphragm paralysis.
- It serves as an alternative to diaphragm plication, offering functional restoration.
- A multidisciplinary approach is crucial for achieving optimal long-term results.
Conclusions:
- Phrenic nerve reconstruction is an established surgical treatment for diaphragm paralysis.
- Accurate diagnosis and patient selection are key for successful surgical outcomes.
- Specialty centers utilizing a multidisciplinary approach are essential for comprehensive care.
Keywords:
Cervical tetraplegiaDiaphragm paralysisDiaphragm plicationPhrenic nerve injuryPhrenic nerve reconstructionPhrenic neurolysisPhrenic neurotizationVentilator dependencyMore Related Videos
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