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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Updated: Aug 30, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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Disseminated Kaposi Sarcoma.

Jin-Yuan Ma1, Jia-Wei Liu2

  • 1The Second School of Clinical Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|August 29, 2022
PubMed
Summary
This summary is machine-generated.

AIDS-associated Kaposi sarcoma (KS), a common HIV neoplasm, can present in the mouth and spread internally. Chemotherapy effectively treated a patient with disseminated KS affecting the oral cavity, skin, and esophagus.

Keywords:
AIDSAIDS-associated Kaposi sarcomachemotherapydisseminated Kaposi sarcomaoral Kaposi sarcoma

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Area of Science:

  • Oncology
  • Infectious Diseases
  • Dermatology

Background:

  • AIDS-associated Kaposi sarcoma (KS) is the most frequent HIV-associated neoplasm.
  • Disseminated KS has become infrequent due to antiretroviral therapy.
  • Oral KS in AIDS patients indicates a poorer prognosis compared to cutaneous lesions alone.

Observation:

  • A 40-year-old male patient presented with ulcerated, violaceous plaques on his hard palate.
  • Similar lesions were found on his left groin and anus.
  • Upper gastrointestinal endoscopy revealed lesions on the esophagus and gastric fundus.

Findings:

  • Histological examination confirmed Kaposi sarcoma (KS).
  • The patient received five cycles of doxorubicin chemotherapy.
  • Significant regression of oral, skin, and esophageal lesions was observed post-treatment.

Implications:

  • This case highlights the potential for disseminated KS in HIV patients.
  • Doxorubicin chemotherapy demonstrated efficacy in treating disseminated KS.
  • Early diagnosis and treatment are crucial for managing complex KS presentations.