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Related Experiment Videos

Strain differences in phenobarbital-induced teratogenesis in mice.

R H Finnell, H E Shields, S M Taylor

    Teratology
    |April 1, 1987
    PubMed
    Summary

    Most anticonvulsant drugs, like phenobarbital, can cause birth defects in pregnant individuals. This study found genetic differences in mice influence sensitivity to these drug-induced congenital abnormalities.

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    Area of Science:

    • Pharmacology
    • Developmental Toxicology
    • Genetics

    Background:

    • Anticonvulsant drugs are frequently prescribed during pregnancy, with over 11,500 pregnancies complicated annually in the US.
    • While the teratogenicity of all anticonvulsants is not fully understood, many can cause congenital abnormalities in susceptible individuals.

    Purpose of the Study:

    • To investigate the influence of genetic background on susceptibility to phenobarbital-induced malformations.
    • To assess the teratogenic potential of phenobarbital across different inbred mouse strains.

    Main Methods:

    • Three inbred mouse strains (SWV, C57BL/6J, LM/Bc) were administered phenobarbital orally over a chronic period.
    • Dose-dependent effects of phenobarbital on fetal development were evaluated, examining skeletal, cardiac, renal, neural, and urogenital systems.

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    Main Results:

    • Phenobarbital demonstrated significant teratogenic potential in mice, inducing multiple types of congenital defects in a dose-related manner.
    • The LM/Bc mouse strain exhibited the highest sensitivity, with 46.7% of fetuses showing malformations at high drug concentrations.
    • The C57BL/6J strain was most resistant, with only 28.6% of fetuses displaying abnormalities.

    Conclusions:

    • Genotype significantly impacts sensitivity to phenobarbital-induced teratogenicity.
    • Mouse models reveal varying susceptibility to drug-induced congenital abnormalities, highlighting the role of genetic factors in developmental toxicology.