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Fibronectin during thyroid hormone replacement therapy.

H Watzke, H P Schwarz, M Weissel

    Thrombosis Research
    |April 15, 1987
    PubMed
    Summary
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    Thyroid function significantly impacts hemostasis. Post-thyroidectomy patients showed decreased fibronectin, which normalized with L-thyroxine replacement, correlating positively with total T4 levels.

    Area of Science:

    • Endocrinology
    • Hematology
    • Surgical Oncology

    Background:

    • Thyroid hormones play a role in various physiological processes.
    • Alterations in thyroid function can potentially influence hemostasis.
    • Fibronectin is a glycoprotein involved in hemostasis and tissue repair.

    Purpose of the Study:

    • To investigate the effect of thyroid function on plasma fibronectin levels.
    • To assess changes in fibronectin and Factor V activity after total thyroidectomy and subsequent L-thyroxine replacement therapy.

    Main Methods:

    • Studied 13 untreated patients post-thyroidectomy for thyroid carcinoma.
    • Measured plasma fibronectin concentrations before and after L-thyroxine replacement.
    • Compared patient groups to healthy volunteers.

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  • Assessed Factor V activity in patient groups.

    • Main Results:

    • Significantly decreased fibronectin levels in untreated patients compared to controls (p < 0.0005).
    • Fibronectin levels significantly increased after L-thyroxine replacement therapy.
    • A significant positive correlation was observed between plasma fibronectin and total T4 levels (r = 0.92).
    • Factor V activity was low in untreated patients and normalized with therapy.

    Conclusions:

    • Thyroid function significantly influences plasma fibronectin levels.
    • L-thyroxine replacement therapy restores fibronectin levels in hypothyroid patients.
    • Fibronectin may serve as a marker for thyroid hormone status in relation to hemostasis.