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Multifocal brain abscesses caused by invasive Streptococcus intermedia: A case report
Lin Yao1, Sansong Chen1, Zuan Yu1
1Department of Neurosurgery, The Translational Research Institute for Neurological Disorders, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, China.
Frontiers in Neurology
|August 29, 2022
Summary
Multifocal brain abscesses caused by Streptococcus intermedia are rare. Meta-genomic next-generation sequencing (mNGS) identified the pathogen, enabling rapid, targeted antibiotic treatment and a successful patient recovery.
Area of Science:
- Neurology
- Infectious Diseases
- Medical Diagnostics
Background:
- Multifocal brain abscesses are uncommon neurological infections.
- Invasive *Streptococcus intermedia* is a rare causative agent of brain abscesses.
Observation:
- A 67-year-old male presented with unconsciousness and fever.
- CT revealed intracranial space-occupying lesions and lung changes.
- Cerebrospinal fluid analysis indicated bacterial meningitis but without pathogen detection in cultures.
Findings:
- Meta-genomic next-generation sequencing (mNGS) of CSF and sputum identified *S. intermedia*.
- Targeted antibiotic therapy based on mNGS results led to rapid clinical improvement.
Implications:
- mNGS is a valuable tool for identifying pathogens in brain abscesses.
- This technique aids in timely clinical diagnosis and effective treatment strategies.
- Early pathogen identification improves patient outcomes in complex infections.
