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Predictive Factors for Surgical Intervention in Neonates with Necrotizing Enterocolitis: A Retrospective Study
Lei Yu1, Chao Liu2, Qingjing Du1
1Children's Hospital, Capital Institute of Pediatrics, Department of Hospital Infection Administrative, Beijing, China.
Frontiers in Surgery
|August 29, 2022
Summary
Procalcitonin levels and gestational age are key indicators for predicting surgery in neonatal necrotizing enterocolitis (NEC). These factors help determine the need for surgical intervention in infants with NEC.
Area of Science:
- Neonatal Medicine
- Pediatric Surgery
- Biomarker Research
Background:
- Current clinical and pathological indicators for predicting surgery in neonatal necrotizing enterocolitis (NEC) are limited.
- This study aimed to identify risk factors for surgical intervention in NEC.
Purpose of the Study:
- To retrospectively analyze neonatal NEC characteristics.
- To identify independent risk factors for surgical intervention in NEC.
Main Methods:
- Retrospective analysis of 184 NEC cases (2015-2019).
- Data divided into surgical (n=41) and conservative (n=143) groups.
- Univariate and multivariate logistic regression, ROC curve analysis.
Main Results:
- Procalcitonin and gestational age were independent predictors of surgical intervention in NEC.
- Procalcitonin (AUC=0.864), CRP (AUC=0.783), and fibrinogen (AUC=0.720) showed significant predictive performance for surgical NEC.
Conclusions:
- Procalcitonin levels and gestational age are crucial independent surgical indications for neonates with NEC.
- These biomarkers can aid in clinical decision-making for NEC management.
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