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Non-coding RNAs in skin cancers:Biological roles and molecular mechanisms

Fei Liu1, Shenglong Li1

  • 1Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Frontiers in Pharmacology
|August 29, 2022
PubMed

Insights

Noncoding RNAs are key to understanding skin cancer metastasis. Research into these molecules may reveal new therapeutic targets for improving patient survival rates in cutaneous malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cutaneous malignancies, such as basal cell carcinoma, squamous cell carcinoma, and melanoma, are increasing globally.
  • Malignant invasion and metastasis are the primary causes of mortality in skin cancer patients.
  • The molecular underpinnings of oncogenes are crucial for developing targeted therapies.

Purpose of the Study:

  • To review the role of noncoding RNAs in the metastatic mechanisms of skin malignancies.
  • To highlight the potential of noncoding RNAs as therapeutic targets.

Main Methods:

  • Literature review focusing on noncoding RNAs (microRNAs, long noncoding RNAs, circular RNAs) and their involvement in skin cancer metastasis.
  • Analysis of current research on the molecular biology of noncoding RNAs in cutaneous malignancies.

Main Results:

  • Noncoding RNAs play significant roles in the complex processes of tumor invasion and metastasis in skin cancers.
  • Specific noncoding RNAs are implicated in various stages of skin cancer progression and spread.

Conclusions:

  • Understanding the function of noncoding RNAs in skin cancer metastasis is critical for advancing treatment strategies.
  • Further research into noncoding RNAs offers promising avenues for novel therapeutic targets and improved patient outcomes in cutaneous malignancies.
Keywords:
malignant progressionmetastasismolecular biologynon-coding RNAskin cancers

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