Related Experiment Video
Updated: Aug 30, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Association Between High-Sensitivity C-Reactive Protein and Prognosis of Patients with Acute Cerebral Infarction
Yuting Pu1,2, Shuangyang Li2, Lingxue Wang2
1LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
Insights
Serum high-sensitivity C-reactive protein (hs-CRP) is a strong predictor of poor prognosis in acute cerebral infarction (ACI). Elevated hs-CRP levels are associated with worse outcomes and can help identify patients needing closer monitoring.
Area of Science:
- Neurology
- Biochemistry
- Inflammation Research
Background:
- Acute cerebral infarction (ACI) poses significant challenges in predicting patient outcomes.
- Biomarkers reflecting inflammatory processes are crucial for understanding stroke severity and prognosis.
Purpose of the Study:
- To investigate the association between serum high-sensitivity C-reactive protein (hs-CRP) levels and the severity of neurological deficits.
- To evaluate the predictive value of hs-CRP for prognosis in patients with acute cerebral infarction (ACI).
Main Methods:
- Retrospective analysis of 119 ACI patients.
- Serum hs-CRP levels measured via latex-enhanced immunoturbidimetric assay.
- Neurological deficit and prognosis assessed using NIHSS and mRS scores; multivariate logistic analysis and ROC curves employed.
Main Results:
- Lower hs-CRP levels correlated with better prognosis (mRS 0-2) compared to worse prognosis (mRS 3-6).
- hs-CRP was independently associated with NIHSS and mRS scores.
- High hs-CRP was an independent predictor of poor ACI prognosis (AUC=0.986), particularly in large-artery atherosclerosis (LAA) subtypes.
Conclusions:
- Serum hs-CRP is a valuable independent predictor of prognosis in ACI patients.
- hs-CRP serves as an efficient biomarker for discriminating ACI severity and prognosis.
- The predictive value of hs-CRP is especially notable in patients with large-artery atherosclerosis (LAA).
Purpose:
To investigate the association of serum high-sensitivity C-reactive protein (hs-CRP) with the severity of neurological deficits and prognosis in patients with acute cerebral infarction (ACI).
Patients And Methods:
In this retrospective analysis, 119 patients with ACI were recruited from January to December 2020. The serum hs-CRP level was measured by a latex-enhanced immunoturbidimetric assay. The severity of neurological deficits and prognosis of ACI patients were assessed using the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Scale (mRS). Multivariate logistic analysis was performed and receiver operating characteristic (ROC) curves were plotted to evaluate the value of hs-CRP in predicting the prognosis of ACI.
Results:
The patients with a more favorable prognosis (mRS score 0-2) had a lower median serum hs-CRP level than those with a worse prognosis (mRS score 3-6) (3.32 IQR: 1.51, 8.04 to 17.93 IQR:16.02, 19.01; P<0.001). After adjusting for potential confounders, multivariable linear regression showed that serum hs-CRP level was independently associated with NIHSS score (Beta = 0.952, P<0.001) and mRS score (Beta=0.878, P<0.001). Multivariate logistic analysis revealed that high hs-CRP level was an independent predictor of the poor prognosis in patients with ACI (adjusted1 OR = 1.995; 95% CI = 1.499-2.655; adjusted2 OR = 2.75; 95% CI = 1.015-7.457). ROC curve analysis indicated that the area under the curve for hs-CRP to predict poor prognosis was 0.986. The cutoff value, sensitivity, and specificity were 11.835 mg/L, 95%, and 92.5%, respectively. In terms of ischemic stroke subtypes, the serum hs-CRP level was higher in large-artery atherosclerosis (LAA) patients than in those with small-artery occlusion (SAO) and cardioembolism (CE). In addition, the patients with LAA had higher scores of NIHSS and mRS than those with SAO and CE.
Conclusion:
Serum hs-CRP level is an independent predictor of prognosis, and an efficient index to discriminate patients with ACI, especially for those with LAA.
More Related Videos
05:16Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
09:41Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome I: Introduction
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations