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Genetic Predisposition to Severe COVID-19 Might Increase the Risk of Stroke: A Two-Sample Mendelian Randomization

Jinji Zhang1, Fayong Wu1, Shenge Chen1

  • 1Sanming Second Hospital, Sanming, China.

Frontiers in Genetics
|August 29, 2022
PubMed

Insights

Severe COVID-19 infection increases the risk of stroke, including ischemic stroke. This finding highlights the need for increased vigilance and care for patients experiencing severe coronavirus disease 2019 (COVID-19).

Area of Science:

  • Genetics
  • Epidemiology
  • Neurology

Background:

  • The causal link between COVID-19 and stroke remains unclear.
  • Investigating this relationship is crucial for public health.
  • Mendelian randomization (MR) offers a robust method to explore causality.

Purpose of the Study:

  • To determine if COVID-19 infection causally increases stroke risk.
  • To differentiate the effects of hospitalization versus severe symptoms.
  • To utilize genetic data for causal inference.

Main Methods:

  • Two-sample Mendelian randomization (MR) was employed.
  • Genome-wide association study (GWAS) data for COVID-19 and stroke were utilized.
  • Inverse variance weighted (IVW) analysis and sensitivity analyses were performed.

Main Results:

  • Hospitalization due to COVID-19 showed a significant positive association with stroke risk (OR=1.05) and ischemic stroke (OR=1.06).
  • Severe respiratory symptoms from COVID-19 were linked to increased stroke risk (OR=1.04) and ischemic stroke (OR=1.06).
  • Statistical significance was observed across key analyses, supporting a causal effect.

Conclusions:

  • Severe COVID-19 infection is a potential causal factor for increased stroke risk.
  • Patients with severe COVID-19 require heightened monitoring for cerebrovascular events.
  • Further research may elucidate specific mechanisms linking severe COVID-19 to stroke.

Keywords:
COVID-19Mendelian randomizationischemic strokeseveritystroke

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