Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomimetic catalase-engineered black phosphorus nanosheets enhance photo-/radio-therapy for hepatocellular carcinoma.

Biomedical materials (Bristol, England)·2026
Same author

The Role of High-Intensity Focused Ultrasound as a Local Consolidative Therapy in Multimodal Conversion Treatment for Colorectal Liver Metastases: A Case Series.

Technology in cancer research & treatment·2026
Same author

Fully automated free-breathing cardiac magnetic resonance imaging at 3T: A prospective randomized study of image quality, efficiency, and workflow burden.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance·2026
Same author

Design, synthesis, and antifungal activity of licochalcone A derivatives and mechanism of action against Phytopathogenic Fungi.

Bioorganic chemistry·2026
Same author

Bistable Otx2-Id1 circuitry governs a developmental transition state in the pluripotency continuum.

The Journal of cell biology·2026
Same author

CD276 promotes CD36-mediated lipid metabolism and confers resistance to tyrosine kinase inhibitors.

Cancer letters·2026

Related Experiment Video

Updated: Aug 30, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

5.7K

APAview: A web-based platform for alternative polyadenylation analyses in hematological cancers.

Xi Hu1, Jialin Song1, Jacqueline Chyr2

  • 1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Frontiers in Genetics
|August 29, 2022
PubMed
Summary

APAview is a new web tool simplifying the analysis of alternative polyadenylation (APA) in hematologic cancers. It enables researchers to explore APA features and perform statistical analyses for better understanding of cancer development.

Keywords:
Flask frameworkalternative polyadenylationdata explorationdata visualizationhematological cancerpost-transcriptional regulationweb interface

More Related Videos

Adapting 3' Rapid Amplification of CDNA Ends to Map Transcripts in Cancer
09:38

Adapting 3' Rapid Amplification of CDNA Ends to Map Transcripts in Cancer

Published on: March 28, 2018

12.4K
Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques
08:16

Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques

Published on: January 12, 2024

1.1K

Related Experiment Videos

Last Updated: Aug 30, 2025

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data
08:35

Identification of Alternative Splicing and Polyadenylation in RNA-seq Data

Published on: June 24, 2021

5.7K
Adapting 3' Rapid Amplification of CDNA Ends to Map Transcripts in Cancer
09:38

Adapting 3' Rapid Amplification of CDNA Ends to Map Transcripts in Cancer

Published on: March 28, 2018

12.4K
Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques
08:16

Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques

Published on: January 12, 2024

1.1K

Area of Science:

  • Bioinformatics
  • Genomics
  • Cancer Research

Background:

  • Hematologic malignancies like acute promyelocytic leukemia (APL) and acute myeloid leukemia (AML) originate in blood-forming tissues.
  • Genetic and molecular alterations, including mutations and gene expression changes, often drive these cancers.
  • Alternative polyadenylation (APA) dysregulation is implicated in hematological malignancies, affecting gene expression.

Purpose of the Study:

  • To develop a user-friendly, web-based platform, APAview, for exploring APA features in hematologic cancers.
  • To simplify the time-consuming and laborious processes of APA data pre-processing, analysis, and visualization.
  • To facilitate APA feature screening and mining for disease research.

Main Methods:

  • APAview is a server-client web platform utilizing Python3, Flask, Jinja2, Bootstrap, and Plotly.
  • It supports the interactive analysis of multimodal data, including APA quantification (QAPA/DaPars), gene expression, and clinical information.
  • The platform allows for correlation, survival, and differential analyses across user-defined groups.

Main Results:

  • APAview was successfully used to explore APA features in APL and AML.
  • The platform demonstrated the capability to handle and analyze multimodal data interactively.
  • APAview can be adapted for analyzing APA features in other diseases by uploading relevant experimental data.

Conclusions:

  • APAview provides a comprehensive and accessible tool for APA analysis in hematologic cancers.
  • The platform streamlines the investigation of APA's role in cancer development, diagnosis, and treatment.
  • APAview has the potential to accelerate research in both hematologic malignancies and other diseases involving APA.