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DNA Damage Repair and Current Therapeutic Approaches in Gastric Cancer: A Comprehensive Review

Menghui Wang1, Chuan Xie1

  • 1Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Genetics
|August 29, 2022
PubMed

Insights

DNA damage repair is crucial for genomic stability. This review explores DNA repair mechanisms in gastric cancer and novel therapeutic strategies targeting these pathways for cancer treatment.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • DNA damage is a constant cellular threat from internal and external factors.
  • Effective DNA repair mechanisms are essential for maintaining genomic integrity.
  • Dysfunctional DNA repair is linked to diseases like cancer and autoimmune disorders.

Purpose of the Study:

  • To review DNA damage repair mechanisms in gastric cancer.
  • To identify DNA damage types contributing to gastric cancer development.
  • To explore novel therapeutic strategies targeting DNA repair pathways in gastric cancer.

Main Methods:

  • Literature review of DNA damage repair pathways.
  • Analysis of DNA damage types in gastric cancer etiology.
  • Examination of emerging therapeutic targets in DNA repair.

Main Results:

  • Gastric cancer development is influenced by specific DNA damage types.
  • DNA damage repair pathways represent promising targets for gastric cancer therapy.
  • PARP inhibitors are an example of successful targeted therapy.

Conclusions:

  • Understanding DNA repair is key to combating gastric cancer.
  • Targeting DNA repair pathways offers new avenues for cancer treatment.
  • Further research into DNA repair mechanisms can advance gastric cancer therapies.
Keywords:
DNA damage repairHelicobacter pyloriPARP inhibitorsgastric cancertherapeutic approaches

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