Apparent Diffusion Coefficient Values and Dynamic Contrast-Enhanced Magnetic Resonance Perfusion are Potential...

Area of Science:

• Neuroradiology
• Oncology
• Medical Imaging

Background:

• Distinguishing high-grade from low-grade meningiomas is clinically significant for treatment and prognosis.
• Conventional MRI often shows overlap between meningioma grades.
• Advanced MRI techniques like ADC and DCE-MRI may offer better differentiation.

Purpose of the Study:

• To evaluate the efficacy of apparent diffusion coefficient (ADC) values and dynamic contrast enhancement (DCE)-MRI parameters in differentiating high-grade from low-grade meningiomas.
• To identify specific MRI parameters that can predict meningioma grade.

Main Methods:

• Retrospective analysis of meningioma patient data from January 2020 to December 2021.
• Evaluation of MRI results including mean ADC value and DCE parameters (TIC, SImax, Tmax, MCER, slope).
• Comparison of MRI parameters between pathologically confirmed high-grade and low-grade meningiomas.

Main Results:

• Mean ADC and Tmax values were significantly lower in high-grade meningiomas compared to low-grade.
• High-grade meningiomas showed significantly higher TIC, SImax, MCER, and slope.
• Optimal cut-offs for ADC (0.87 × 10^-3 mm²s^-1) and Tmax (42 s) demonstrated high diagnostic performance.
• Specific cut-offs for SImax (940.2), MCER (245%), and slope (5% per second) also showed excellent sensitivity and specificity.

Conclusions:

• ADC values and DCE-MRI parameters (TIC, SImax, Tmax, MCER, slope) are effective predictors for distinguishing high-grade from low-grade meningiomas.
• These advanced MRI metrics can aid in precise diagnosis and treatment planning.
• Further validation may establish these parameters as standard tools in meningioma assessment.