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Related Experiment Video

Updated: Aug 30, 2025

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[DNA methylation in experimental ischemic brain injury].

N S Shcherbak1, I O Suchkova2, E L Patkin2

  • 1Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 29, 2022
PubMed
Summary

DNA methylation is increasingly relevant to understanding cerebral ischemia and stroke pathogenesis. Animal studies show DNA methylation changes in the brain are linked to ischemic stroke development and may serve as a biomarker.

Keywords:
DNA methylationbiomarkersbrainepigeneticsischemic stroke

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Area of Science:

  • Neuroscience
  • Epigenetics
  • Molecular Biology

Background:

  • Cerebral ischemia and stroke pathogenesis are increasingly understood through angioneurology.
  • Epigenetic mechanisms, particularly DNA methylation, are crucial in stroke development and brain damage.
  • Understanding DNA methylation's role in cerebral ischemia is a growing area of research.

Purpose of the Study:

  • To review animal studies investigating the relationship between DNA methylation and cerebral ischemia.
  • To analyze the current evidence on DNA methylation's impact on ischemic stroke development and pathogenesis.

Main Methods:

  • Systematic literature search of PubMed database using relevant keywords.
  • Selection and analysis of 282 articles, focusing on 8 genome-wide DNA methylation studies and 6 candidate gene studies in experimental cerebral ischemia.
  • Review of findings from animal models of ischemic stroke.

Main Results:

  • Animal studies demonstrate a clear association between brain DNA methylation and the development of ischemic stroke.
  • Changes in DNA methylation levels were observed in specific genes following ischemic events.
  • Two studies reported decreased DNA methylation in 2 genes, while four studies found increased methylation in 8 genes in ischemic brain tissues.

Conclusions:

  • Brain DNA methylation is implicated in the pathogenetic mechanisms of ischemic stroke in animal models.
  • DNA methylation patterns in stroke are a promising area for identifying biomarkers.
  • Assessing DNA methylation levels could aid in developing and improving therapeutic strategies for ischemic and reperfusion injury.