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Updated: Aug 30, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
New Diterpene and Indole Alkaloid Analogs from the Streptomyces malaysiensis SCSIO 41397
Yuhui Xie1,2, Yue Song1, Ziwen Cong1,2
1CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, P. R. China.
Abstract:
One new cyclooctatin-type diterpenoid, 15-hydroxycyclooctatin (1), and one new indole alkaloid, streptoprenylindole D (3), along with 9 known compounds, were isolated from the Streptomyces malaysiensis SCSIO 41397. Their structures were established on the basis of spectroscopic analysis, optical rotation, and by a comparison with data from the literature. All isolated compounds were evaluated for their antibacterial (MRSA), antitumor (22Rv1 and PC-3) and antiviral (HSV-1/2) activities. According to the analysis of biological gene clusters in the whole genome, we preliminarily locate the gene clusters related to the synthesis of 15-hydroxycyclooctatin (1).
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