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Related Experiment Video

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Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
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A technique for excisional optic nerve biopsy.

Edsel B Ing1, Georges Nassrallah1, Navdeep Njihawan1

  • 1Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Canada.

Orbit (Amsterdam, Netherlands)
|August 29, 2022
PubMed
Summary
This summary is machine-generated.

This study details a safe transconjunctival technique for excisional optic nerve biopsy, enabling the collection of large specimens without harming the eye. This method offers a viable alternative to endoscopic procedures.

Keywords:
Biopsyoptic nerve

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Area of Science:

  • Ophthalmology
  • Neurosurgery
  • Surgical Techniques

Background:

  • Optic nerve biopsy is crucial for diagnosing various optic neuropathies.
  • Traditional biopsy methods may involve risks or limitations in specimen size.

Purpose of the Study:

  • To describe a novel transconjunctival technique for performing a full-thickness, excisional optic nerve biopsy.
  • To evaluate the safety and efficacy of this minimally invasive approach.

Main Methods:

  • A medial transconjunctival approach was utilized, involving temporary disinsertion of the medial rectus muscle.
  • A posterior optic nerve clamp and microscalpel were employed for precise, full-thickness nerve transection.
  • The optic nerve was rotated anteriorly to complete the proximal cut.

Main Results:

  • A full-thickness specimen of 11 mm or more was successfully obtained.
  • The technique demonstrated viability of the globe without undue traction.
  • The procedure was performed safely and effectively.

Conclusions:

  • A long-length, excisional optic nerve biopsy can be readily and safely performed using this transconjunctival technique.
  • This method provides a viable alternative to endoscopic approaches for optic nerve biopsy.