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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Stem Cell Niche01:26

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Related Experiment Video

Updated: Aug 30, 2025

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans
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Aging of Skeletal Stem Cells.

M Gohazrua K Butler1, Thomas H Ambrosi1, Matthew P Murphy1,2

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

Advances in Geriatric Medicine and Research
|August 29, 2022
PubMed
Summary
This summary is machine-generated.

Skeletal stem cells (SSCs) show functional declines with aging, impacting bone health. Understanding SSC aging is crucial for developing therapies for age-related skeletal deterioration and improving global health.

Keywords:
agingbonecartilagedegenerationregenerationskeletal stem cells

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Area of Science:

  • Gerontology
  • Stem Cell Biology
  • Skeletal Biology

Background:

  • Skeletal stem cells (SSCs) are vital for lifelong skeletal maintenance and repair.
  • Aging significantly alters SSC function, leading to decreased bone and cartilage production and increased marrow adipose tissue.
  • These changes contribute to skeletal fragility and functional decline in older individuals.

Purpose of the Study:

  • To review the current understanding of skeletal stem cell aging.
  • To explore the micro- and macroscopic aspects of SSC aging.
  • To discuss future research directions and potential therapeutic strategies for age-related skeletal conditions.

Main Methods:

  • Literature review of recent investigations into SSC biology and aging.
  • Analysis of studies focusing on transcriptional regulation, cell function, and identity in aged SSCs.
  • Examination of both cellular and organismal levels of skeletal aging.

Main Results:

  • Aging impairs SSCs' ability to produce bone and cartilage.
  • Alterations in the cellular microenvironment and increased bone marrow adipose tissue are characteristic of skeletal aging.
  • Homogeneous SSC populations with defined phenotypes have facilitated detailed aging studies.

Conclusions:

  • Skeletal stem cell aging is a key factor in the deterioration of the skeletal system.
  • Further research into SSC aging mechanisms is essential for developing effective interventions.
  • Understanding SSC aging is critical for addressing age-related bone diseases and promoting healthy aging.