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Lower Glycated Hemoglobin with Real-Time Continuous Glucose Monitoring Than with Intermittently Scanned Continuous

Lucie Radovnická1,2, Aneta Hásková3, Quoc Dat Do3

  • 1First Faculty of Medicine, Charles University, Prague, Czech Republic.

Diabetes Technology & Therapeutics
|August 29, 2022
PubMed

Insights

Real-time continuous glucose monitoring (rtCGM) showed superior results compared to intermittently scanned continuous glucose monitoring (isCGM) in adults with type 1 diabetes. rtCGM led to lower HbA1c and reduced time spent in hypoglycemia.

Area of Science:

  • Endocrinology
  • Diabetes Management
  • Medical Technology

Background:

  • Type 1 diabetes (T1D) management requires effective glucose monitoring.
  • Continuous glucose monitoring (CGM) systems offer real-time or intermittent data.
  • Comparing the real-world efficacy of different CGM types is crucial for clinical guidance.

Purpose of the Study:

  • To compare the efficacy of real-time continuous glucose monitoring (rtCGM) versus intermittently scanned continuous glucose monitoring (isCGM) in adults with T1D.
  • To evaluate differences in glycated hemoglobin (HbA1c) levels and time spent in hypoglycemia as primary outcomes.
  • To provide clinical insights into CGM device selection for T1D management.

Main Methods:

  • A 12-month, real-world, nonrandomized study (CORRIDA LIFE) involving 191 adults with T1D.
  • Participants were divided into rtCGM (Dexcom G5/G6) and isCGM (FreeStyle Libre 14-Day) groups.
  • Primary endpoint was the difference in HbA1c at 12 months; secondary outcomes included time in hypoglycemia and time in target glucose range.

Main Results:

  • rtCGM group achieved significantly lower HbA1c levels (7.1%) compared to the isCGM group (7.7%) after 12 months (P=0.0001).
  • The rtCGM group spent less time in hypoglycemia (<70 mg/dL and <54 mg/dL) and more time in the target range (70-180 mg/dL) than the isCGM group.
  • Significant differences were observed in time spent in hypoglycemia (P=0.003) and time in target range (P=0.0002).

Conclusions:

  • rtCGM demonstrated superior glycemic control compared to isCGM in adults with T1D over 12 months.
  • rtCGM use was associated with improved HbA1c, reduced hypoglycemia, and increased time in target glucose range.
  • Findings support rtCGM as a more effective monitoring strategy for optimizing T1D management.

Keywords:
Continuous glucose monitoringContinuous subcutaneous insulin infusionFlash glucose monitoringGlycated hemoglobinHypoglycemiaMultiple daily insulin injectionsTime in rangeType 1 diabetes

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