Nanoengineering and green chemistry-oriented strategies toward nanocelluloses for protein sensing

As one of the most important functional organic macromolecules of life, proteins not only participate in the cell metabolism and gene regulation, they also earnestly protect the body's immunity system, leading to a powerful biological shield and homeostasis. Advances in nanomaterials are boosting the significant progress in various applications, including the sensing and examination of proteins in trace amount. Nanocellulose-oriented protein sensing is at the forefront of this revolution. The inherent feature of high biocompatibility, low cytotoxicity, high specific area, good durability and marketability endow nanocellulose with great superiority in protein sensing. Here, we highlight the recent progress of protein sensing using nanocellulose as the biosensor in trace amount. Besides, various kinds of construction strategies for nanocelluloses-based biosensors are discussed in detail, to enhance the agility and accuracy of clinical/medical diagnostics. Finally, several challenges in the approbatory identification of new approaches for the marketization of biomedical sensing that need further expedition in the future are highlighted.