Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K
Tumor Immunotherapy01:27

Tumor Immunotherapy

644
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
644

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Impact of fertility preservation on quality of life, recurrence and reproductive success in young female cancer survivors: a Korean prospective multicentre cohort study protocol (LIFE-Repro).

BMJ open·2026
Same author

Long-Term Outcomes in Patients With Recurrent Ovarian Cancer and Exceptional Response to PARP Inhibitors.

JAMA oncology·2026
Same author

Evolution of siRNA Therapeutics: From Mechanistic Foundations to Clinical Expansion.

Pharmaceutics·2026
Same author

Neutrophil-Like Mitochondria Enable Blood-Brain Barrier Transmigration and Neuroprotection.

ACS nano·2026
Same author

Factors affecting health-related quality of life in cervical cancer survivors: a multicenter cross-sectional study in Korea.

BMC women's health·2026

Related Experiment Video

Updated: Aug 30, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.8K

DNA-cloaked nanoparticles for tumor microenvironment-responsive activation.

Dongyoon Kim1, Junho Byun1, Se Ik Kim2

  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 29, 2022
PubMed
Summary

Researchers developed novel DNA nanothread-cloaked nanoparticles that selectively release anticancer drugs in reactive oxygen species (ROS)-rich tumor environments. This targeted delivery system effectively reduced tumor volume by 80% in preclinical studies.

Keywords:
DNA nanothreadDNA-cloaked nanoparticlesReactive oxygen speciesSelective activationTumor microenvironment

More Related Videos

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

473
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.8K

Related Experiment Videos

Last Updated: Aug 30, 2025

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

2.8K
Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases
09:48

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

473
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

16.8K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Developing targeted drug delivery systems that respond to specific tumor microenvironment (TME) stimuli is crucial for improving cancer therapy.
  • Current TME-responsive systems have a limited range of triggering stimuli.
  • Reactive oxygen species (ROS) are abundant in many tumors and can induce DNA fragmentation.

Purpose of the Study:

  • To engineer novel nanoparticles responsive to the ROS-rich TME for targeted drug delivery.
  • To evaluate the efficacy of DNA nanothread-cloaked nanoparticles (DBNP) for delivering omacetaxine.
  • To assess the selective uptake and tumor distribution of DBNP in a cancer model.

Main Methods:

  • Synthesized branched cyclam ligand-modified nanoparticles (BNP) encapsulating omacetaxine.
  • Prepared DNA nanothreads via rolling-circle amplification and complexed them with BNP to form DBNP.
  • Investigated DBNP responsiveness to ROS and cell supernatants.
  • Assessed nanoparticle uptake in ROS-high cancer cells versus ROS-low fibroblast cells.
  • Utilized molecular imaging and mass spectrometry to track drug distribution in vivo.
  • Evaluated tumor volume reduction and transcriptional changes after DBNP treatment in mice.

Main Results:

  • DBNP demonstrated ROS-dependent size and zeta potential changes, indicating payload release.
  • DBNP exhibited significantly higher uptake in ROS-high cancer cells compared to ROS-low cells.
  • Molecular imaging confirmed enhanced DBNP accumulation in tumor tissues.
  • Ex vivo imaging showed omacetaxine metabolites distributed within tumor tissues after DBNP administration.
  • Intravenous administration of DBNP resulted in an 80% reduction in tumor volume.
  • Omacetaxine treatment via DBNP altered the tumor's transcriptional profile.

Conclusions:

  • Polymerized DNA-masked nanoparticles are feasible for selective activation in ROS-rich TMEs.
  • DBNP represents a promising platform for targeted cancer therapy, enhancing drug efficacy and reducing off-target effects.
  • This approach offers a new strategy for developing advanced drug delivery systems responsive to specific tumor characteristics.