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Sex and gender differences in dementia.
Patrick Salwierz1, Carly Davenport1, Vishaal Sumra1
1Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
International Review of Neurobiology
|August 29, 2022
Summary
Understanding dementia is shifting, emphasizing early diagnosis and precision medicine. Biological sex and gender significantly influence dementia presentation and progression, requiring further research.
Area of Science:
- Neuroscience
- Gerontology
- Medical Research
Background:
- Dementia research is evolving, with new insights into neurodegeneration and proteinopathies.
- Protein buildup precedes dementia symptoms, highlighting the need for early diagnosis.
- Accurate diagnosis is crucial for developing targeted, precision medicine approaches.
Purpose of the Study:
- To explore the impact of biological sex and gender on dementia.
- To review current knowledge on how sex and gender influence major dementia causes.
- To identify gaps in understanding regarding sex and gender in dementia.
Main Methods:
- Literature review of recent advances in dementia research.
- Analysis of the role of proteinopathies in disease onset.
- Examination of factors influencing disease manifestation and progression.
Main Results:
- Dementia's pathological processes begin years before clinical symptoms appear.
- Biological sex and gender are critical factors affecting dementia's presentation and progression, alongside age and race.
- Significant knowledge gaps exist regarding the interplay of sex and gender with specific dementia pathologies.
Conclusions:
- The paradigm shift in dementia research necessitates considering individual factors like sex and gender.
- Early diagnosis and precision medicine are key to managing cognitive impairment.
- Further investigation into the influence of biological sex and gender is essential for comprehensive dementia care.
Keywords:
Alzheimer's diseaseCognitive impairmentDementiaDementia with Lewy bodiesFrontotemporal dementiaParkinson's diseaseVascular diseaseMore Related Videos
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