[Percutaneous biliary stent combined with brachytherapy for malignant obstructive jaundice: a multicenter...

Area of Science:

• Interventional Radiology
• Oncology
• Gastroenterology

Background:

• Malignant obstructive jaundice poses significant treatment challenges.
• Percutaneous biliary stenting is a common palliative intervention.
• Enhancing stent patency and patient survival remains a critical goal.

Purpose of the Study:

• To evaluate the efficacy and safety of percutaneous biliary stent combined with iodine-125 seed brachytherapy.
• To identify prognostic factors influencing treatment outcomes.
• To compare this combined approach with standard stenting.

Main Methods:

• Retrospective analysis of 107 patients with malignant obstructive jaundice.
• Comparison between a study group (stent + brachytherapy, n=58) and a control group (stent only, n=49).
• Assessment of bilirubin levels, stent patency, complications, and overall survival (OS).

Main Results:

• No significant difference in complication rates between groups (17.2% vs 18.3%).
• Significantly longer stent patency in the study group (10.0 months vs 5.2 months).
• Significantly longer median OS in the study group (11.2 months vs 8.0 months).

Conclusions:

• Percutaneous biliary stent combined with brachytherapy is safe and effective for malignant obstructive jaundice.
• The combined treatment significantly prolongs biliary stent patency and patient survival.
• Stent combined with brachytherapy and further anti-tumor therapy are independent factors for improved outcomes.