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Related Experiment Video

Updated: Aug 30, 2025

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
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Shrinking Lung Syndrome: A Case Report.

Asma Haji Datoo1, Loui Abdelghani2

  • 1Internal Medicine, St. Joseph's Medical Center, Stockton, USA.

Cureus
|August 30, 2022
PubMed
Summary

Shrinking Lung Syndrome (SLS), a rare complication of systemic lupus erythematosus (SLE), presents with shortness of breath and chest pain. This case highlights SLS diagnosis and steroid treatment in an SLE patient.

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Internal Medicine

Background:

  • Shrinking Lung Syndrome (SLS) is an infrequent complication associated with Systemic Lupus Erythematosus (SLE).
  • SLS is characterized by dyspnea, pleuritic chest pain, and elevated diaphragm, often diagnosed via exclusion.
  • The exact pathogenesis, treatment, and preventative strategies for SLS remain unclear.

Observation:

  • A 41-year-old woman with a history of SLE presented with unexplained pleuritic chest pain and shortness of breath.
  • Diagnostic workup included CTA chest, laboratory tests, chest X-ray, and pulmonary function tests.
  • These investigations were crucial in ruling out other potential causes for her respiratory symptoms.

Findings:

  • The patient was diagnosed with Shrinking Lung Syndrome (SLS) based on clinical presentation and diagnostic findings.
Keywords:
diaphragm dysfunctiondiaphragm injuryrespiratory paralysisshrinking lung syndromesystemic lupus erythematous disease

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  • The diagnostic process involved a comprehensive exclusion of alternative conditions.
  • The diagnosis was confirmed after excluding other causes of dyspnea.
  • Implications:

    • This case underscores the importance of considering SLS in SLE patients presenting with respiratory symptoms.
    • Treatment with corticosteroids was initiated, guided by limited existing research.
    • Further research is warranted to elucidate SLS pathogenesis and establish definitive treatment protocols.